克罗米苯对男性低促性腺素性功能减退症有效

纽约（保险业社健康版）1年底四日报道：据发表在12年底出版的《生孩子与不育》杂志的一项报告反驳克罗米胺对部分高于促性腺亦同性功能减退的女性病患者稳固。来自伯明翰阿拉巴马大学的该报告的第一作者Scott J. Whitten芝加哥大学在接受保险业新闻机构采访时时说：“上皮细胞或获得性HH病患者在接受妨碍性更多和更为便宜的化疗（例如注射促性腺激亦同类）前顺利进行4个年底的克罗米胺试验性化疗是稳固的。”Whitten芝加哥大学和同僚学术研究了克罗米胺对10名HH女性病患者（HH是避免女性不育的少见因亦同）是否有效。报告称克罗米胺化疗1年后，4名卡尔曼(氏)综合征病患者中只有一名病患者的胎盘溶解度提高而全垂体功能减退症病患者的胎盘缺乏腹泻均没得到改善。相反，该报告反驳3名成年发病的上皮细胞HH女性病患者经过3个年底克罗米胺的化疗胎盘溶解度有了明显提高。已确定该组病患者已有两名恢复了生孩子能力。Whitten芝加哥大学时说：“除非对克罗米胺化疗没反应会，我们不会因为副作用停止对病患者使用该药物。”再次作者总结时说：“因为条件有限，对HH病患者促性腺激亦同抑制剂和克罗米胺的随机学术研究不足以顺利进行，然而利用多系列的严格选择标准对病患者顺利进行分级可能会帮助全面解析克罗米胺恢复女性高于生孩子能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰稿：蓝色幻想

撰稿： 张靖