克罗米酚对男性更高促性腺素性功能减退症有效

纽约（路透社心理健康版）1年末四日报道：据撰写在12年末出版的《生育与生子》杂志的一项研究报告指出克罗米衍生物对部分较低促性腺素性功能性减退的异性恋病征有利。来自伯明翰阿拉巴马大学的该研究报告的第一译者Scott J. Whitten博士在接受路透通讯社采访谈到：“原发性或获得性HH病征在接受侵害性大得多和相当较贵的化疗（例如注射促性腺激素类）前开展4个年末的克罗米衍生物试验性化疗是有利的。”Whitten博士和同事研究了克罗米衍生物对10名HH异性恋病征（HH是随之而来异性恋生子的少见环境因素）是否有效地。研究报告指克罗米衍生物化疗1年后，4名卡尔曼(氏)综合征病征里只有一名病征的受精卵剂量缩减而全垂体功能性减退症病征的受精卵缺乏症状均不能得到改善。相反，该研究报告指出3名未成年发病的原发性HH异性恋病征经过3个年末克罗米衍生物的化疗受精卵剂量有了明显缩减。目前为止该组病征早两名恢复了生殖。Whitten博士感叹：“除非对克罗米衍生物化疗不能自由基，我们才会因为症状停止对病征应用于该药物。”就此译者总结感叹：“因为前提有限，对HH病征促性腺激素类药物和克罗米衍生物的随机研究难以开展，然而利用多系列的完全符合选择标准对病征开展分级有可能帮助进一步验证克罗米衍生物恢复异性恋较低生殖的有效地性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：粉红色虚幻

编辑： 张靖